Warning should be exercised when administering Promethazine HCl Oral Solution to pediatric patients two years of age and older due to opportunity for deadly respiratory melancholy. Respiratory depression and apnea, occasionally linked to Loss of life, are strongly connected with Promethazine products and so are not directly relevant to individualized pounds-centered dosing, which could or else permit Protected administration.
It is crucial that Promethazine HCl Oral Solution is measured using an accurate measuring system (see Safety measures-Information and facts for Clients). A residence teaspoon is just not an correct measuring unit and could lead to overdosage, especially when fifty percent a teaspoon will be to be measured.
A possibly lethal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) is claimed in association with promethazine HCl by itself or in combination with antipsychotic medicines.
DailyMed will deliver this notification towards your desktop, Internet browser, or e-mail with regards to the RSS Reader you select to utilize. To view up-to-date drug label one-way links, paste the RSS feed deal with (URL) revealed beneath into a RSS reader, or make use of a browser which supports RSS feeds, such as Safari for Mac OS X.
Promoting or freely giving Promethazine Hydrochloride and Codeine Phosphate Oral Solution may perhaps hurt Many others, and is particularly versus the regulation. Notify your Health care service provider Should you have ever abused or been depending on Alcoholic beverages, prescription medicines or Road medication.
Narcotic analgesics may possibly induce nausea and more info vomiting by stimulating the chemoreceptor induce zone (CTZ); nevertheless, Additionally they depress the vomiting Heart, to make sure that subsequent doses are not likely to generate vomiting. Nausea is minimal soon after common oral doses of codeine.
Usual Grownup dosage is 50 mg Promethazine using an properly reduced dose of narcotic or barbiturate plus the needed amount of a belladonna alkaloid.
Excessively significant dosages of antihistamines, which include Promethazine HCl Oral Remedy, in pediatric patients may well result in unexpected Loss of life (see OVERDOSAGE). Hallucinations and convulsions have happened with therapeutic doses and overdoses of Promethazine in pediatric sufferers. In pediatric patients that are acutely unwell connected to dehydration, There is certainly an elevated susceptibility to dystonias with the use of Promethazine HCl.
sedation, relief of stress, and manufacture of light-weight slumber from which the individual might be conveniently aroused
The following laboratory assessments could be influenced in sufferers who are obtaining therapy with promethazine HCl:
As a result of pitfalls of dependancy, abuse, and misuse with opioids, even at recommended doses [see Warnings and Safeguards (five.1)], reserve Promethazine HCl and Codeine Phosphate Oral Remedy to be used in adult sufferers for whom the key benefits of cough suppression are expected to outweigh the pitfalls, As well as in whom an suitable assessment in the etiology with the cough has long been manufactured.
Concomitant administration of Promethazine solutions with other respiratory depressants has an association with respiratory depression, and occasionally Dying, in pediatric people.
Clearance could possibly be lowered as well as the metabolites might accumulate to much bigger plasma degrees in sufferers with renal failure in comparison with patients with ordinary renal operate.
The diagnostic evaluation of clients with this syndrome is intricate. In arriving at a prognosis, it's important to establish instances where the medical presentation includes the two major health-related health issues (e.